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Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833 | ACS Medicinal Chemistry Letters
Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833 | ACS Medicinal Chemistry Letters

Discovery of Potent Deuterated Compounds as Potential KRASG12D Inhibitors in Cancer Therapy | ACS Medicinal Chemistry Letters
Discovery of Potent Deuterated Compounds as Potential KRASG12D Inhibitors in Cancer Therapy | ACS Medicinal Chemistry Letters

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) | ACS Medicinal Chemistry Letters
Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) | ACS Medicinal Chemistry Letters

Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors | ACS Medicinal Chemistry Letters
Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors | ACS Medicinal Chemistry Letters

Evaluation of 3-Dimensionality in Approved and Experimental Drug Space | ACS Medicinal Chemistry Letters
Evaluation of 3-Dimensionality in Approved and Experimental Drug Space | ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters | Ahead of Print
ACS Medicinal Chemistry Letters | Ahead of Print

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4 | ACS Medicinal Chemistry Letters
Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4 | ACS Medicinal Chemistry Letters

Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series | ACS Medicinal Chemistry Letters
Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series | ACS Medicinal Chemistry Letters

Design, Synthesis, and Anti-HBV Activity of New Bis(l-amino acid) Ester Tenofovir Prodrugs | ACS Medicinal Chemistry Letters
Design, Synthesis, and Anti-HBV Activity of New Bis(l-amino acid) Ester Tenofovir Prodrugs | ACS Medicinal Chemistry Letters

Readily Accessible High-Throughput Experimentation: A General Protocol for the Preparation of ChemBeads and EnzyBeads | ACS Medicinal Chemistry Letters
Readily Accessible High-Throughput Experimentation: A General Protocol for the Preparation of ChemBeads and EnzyBeads | ACS Medicinal Chemistry Letters

ACS Med Chem Lett (@ACSMedChemLett) / Twitter
ACS Med Chem Lett (@ACSMedChemLett) / Twitter

Novel Reagent Space: Identifying Unorderable but Readily Synthesizable Building Blocks | ACS Medicinal Chemistry Letters
Novel Reagent Space: Identifying Unorderable but Readily Synthesizable Building Blocks | ACS Medicinal Chemistry Letters

Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines | ACS Medicinal Chemistry Letters
Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines | ACS Medicinal Chemistry Letters

Relevance of the Trillion-Sized Chemical Space “eXplore” as a Source for Drug Discovery | ACS Medicinal Chemistry Letters
Relevance of the Trillion-Sized Chemical Space “eXplore” as a Source for Drug Discovery | ACS Medicinal Chemistry Letters

Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors | ACS Medicinal Chemistry Letters
Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors | ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters | Vol 11, No 11
ACS Medicinal Chemistry Letters | Vol 11, No 11

Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35 | ACS Medicinal Chemistry Letters
Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35 | ACS Medicinal Chemistry Letters

Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors | ACS Medicinal Chemistry Letters
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors | ACS Medicinal Chemistry Letters

Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors | ACS Medicinal Chemistry Letters
Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors | ACS Medicinal Chemistry Letters

An Innovation 10 Years in the Making: The Stories in the Pages of ACS Medicinal Chemistry Letters | ACS Medicinal Chemistry Letters
An Innovation 10 Years in the Making: The Stories in the Pages of ACS Medicinal Chemistry Letters | ACS Medicinal Chemistry Letters

Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C | ACS Medicinal Chemistry Letters
Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C | ACS Medicinal Chemistry Letters

Discovery and Development of Cyclic Peptide Inhibitors of CIB1 | ACS Medicinal Chemistry Letters
Discovery and Development of Cyclic Peptide Inhibitors of CIB1 | ACS Medicinal Chemistry Letters

Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design | ACS Medicinal Chemistry Letters
Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design | ACS Medicinal Chemistry Letters

Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition | ACS Medicinal Chemistry Letters
Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition | ACS Medicinal Chemistry Letters

Massively Parallel Optimization of the Linker Domain in Small Molecule Dimers Targeting a Toxic r(CUG) Repeat Expansion | ACS Medicinal Chemistry Letters
Massively Parallel Optimization of the Linker Domain in Small Molecule Dimers Targeting a Toxic r(CUG) Repeat Expansion | ACS Medicinal Chemistry Letters